How headache is produced?

Pain usually generated when peripheral nociceptors are stimulated in response to tissue injury, visceral distension, or other factors.In such situations, pain perception is a normal physiologic response mediated by a healthy nervous system.

Pain can also result when pain-producing pathways of the peripheral or central nervous system (CNS) are damaged or activated inappropriately.

Headache may originate from either or both mechanisms.

Relatively few cranial structures are pain-sensitive they are