A site for medical students - Practical,Theory,Osce Notes

How headache is produced?

Pain usually generated when peripheral nociceptors are stimulated in response to tissue injury, visceral distension, or other factors.In such situations, pain perception is a normal physiologic response mediated by a healthy nervous system.
Pain can also result when pain-producing pathways of the peripheral or central nervous system (CNS) are damaged or activated inappropriately.
Headache may originate from either or both mechanisms.
Relatively few cranial structures are pain-sensitive they are
  • Scalp
  • Middle meningeal artery
  • Dural sinuses
  • Falx cerebri
  • Proximal segments of the large pial arteries. 
Structures that are not painsensitive
  • The ventricular ependymal
  • Choroid plexus
  • Pial veins
  • Much of the brain parenchyma