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What is drug fever?

Drug fever has the following clinical features.
  • Drug induced fever is a prolonged fever and it may belong to any febrile pattern given below
  • There is relative bradycardia and hypotension associated with this fever
  • Pruritus, skin rash and arthralgia can occur
  • It begins 1-3 weeks after the start of the drugs and this may persists 2-3 day's after the drug is stopped
  • .Eosinophilia may be present.
Almost all drugs can produce fever.Important commonly used drugs producing fever are
Agents causing drug fever
  • Sulphonamides.
  • Iodides, bromides.
  • Thiouracils.
  • Barbiturates.
  • Rifampicin (‘flu syndrome’)
  • Phenolpthalein (used in laxatives).
  • Quinidine.
  • Phenytoin 
Digoxin does not cause drug fever.