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How will you clinically differentiate between Marfan syndrome and homocystinuria

Marfan's syndrome is characterised by the following
  • It is a connective tissue disorder
  • It is transmitted as an autosomal dominant trait
  • Bones are normal
  • Mitral valve prolapse and dilatation of the aortic root and sinus of Valsalva may be present
  • There is no mental retardation
  • There is superoateral subluxation of the lens
Homocysinuria is characterised by the folowing
  • It is an inborn error of metabolism, due to lack of the enzyme cystathionine synthase, leading to accumulation of homocystine and methionine and a deficiency of cystathionine and cystine
  • It is transmitted as an autosomal recessive trait
  • Mental defect is present
  • Osteoporosis is present 
  • Medial degeneration of the aorta and elastic arteries may be present
  • Arterial  and venous thrombosis can occur
  • Inferolateral subluxation of the lens is seen