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What are the Signs and Symptoms of Cushing’s Syndrome

Cushing syndrome produce changes in body fat,skin,bone,muscle,resproductive system,cardiovasular and blood.
Changes in the body fat
  •          Body fat Weight gain
  •        Central obesity
  •          Rounded face
  •          Fat pad on back of neck (“buffalo hump”)
Changes in the Skin
  •  Facial plethora
  •          Thin and brittle skin
  •          Easy bruising,
  •          Broad and purple stretch marks,
  •          Acne
  • ·        Hirsutism
Changes in Bone
  •         Osteopenia
  •          Osteoporosis (vertebral fractures),
  •         Decreased linear growth in children
Changes in muscle
  •          Muscle Weakness
  •          Proximal myopathy (prominent
  • ·        Atrophy of gluteal and upper leg muscles
Changes Metabolism
  • Glucose intolerance/diabetes
  • Dyslipidemia
  • Changes in the Cardiovascular system
  • Hypertension
  • Hypokalemia,
  • Edema
  • Atherosclerosis 
Reproductive system changes
  • Decreased libido,  amenorrhea in women
Blood and immune system changes
  • Increased susceptibility to infections
  • Increased white blood cell count
  • Eosinopenia,
  • Hypercoagulation with increased risk of deep vein thrombosis and pulmonary embolism
Central nervous system changes
  • Irritability
  • Emotional lability
  • Depression,
  • Cognitive defect and paranoid psychosis