Paradoxical Hypertension
In this form of hypertension, patients paradoxically show an increase in BP. even when on antihypertensive drugs
Examples
- Patients with DM and HTN, on beta blockers, on developing hypoglycacmia show a paradoxical risen over previously well-controlled BP. This is because the excess adrenaline released secondary to hypoglycacmia. This will acts unopposed on the alpha receptors and thereby raises the BP.
- With high doses of clonidine, the peripheral a, receptors are stimulated, apart from its central action, thereby raising the BP.
- In patients with bilateral renal artery stenosis, administration of ACE inhibitors, results in a paradoxical rise in BP.
- Administration of P blockers in patients with pheo- chromocytoma leads to uninhibited a receptor stimulation by epinephrine leading to paradoxical rise in BP.
- Diabetics on beta blockers
- Phaeochromocytoma on beta blockers
- High doses of clonidine
- ACEI in bilateral renal artery stenosis
