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Pathophysiology of unstable angina

1.Plaque rupture or erosion with superimposed nonocclusive thrombus,is believed to be the most common cause 
2. Dynamic obstruction [e.g., coronary spasm, as in Prinzmetal's variant angina] 
3. Progressive mechanical obstruction [e.g., rapidly advancing coronary atherosclerosis or restenosis following percutaneous coronary intervention (PCI)] 
4.Secondary UA related to increased myocardial oxygen demand and/or decreased supply (e.g., anemia). 
More than one of these processes may be involved in many patients.